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Fig. 7 | Respiratory Research

Fig. 7

From: High-dose intranasal application of titanium dioxide nanoparticles induces the systemic uptakes and allergic airway inflammation in asthmatic mice

Fig. 7

Nanoparticle uptake in alveolar macrophages (Cultured alveolar macrophages (a) were exposed to titanium dioxide [TiO2 NPs; 0.0125, 0.025, and 1 mg/mL] and phosphate buffered saline. Cellular uptake was analyzed after incubation for 1, 2, 4, 8, and 24 h. Adherent mouse alveolar macrophages were fixed and stained with DAPI before microscopic analysis. An example image of alveolar macrophage in bronchoalveolar lavage fluid (b) was taken by scanning electron microscopy. The white spot inside the cell is a cluster of TiO2 NPs. This was followed by EDX spectrum analysis showing a strong titanium signal, indicating the presence of TiO2 NPs in alveolar macrophages)

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Respiratory Research

ISSN: 1465-993X

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