Table 1 Histochemical semi-quantitative evaluation of proximal location to treatment site. Hematoxylin-eosin staining was used to evaluate the structural changes. All sections were evaluated on semi-quantitative 1–4 point scale. Values are mean ± SEM
Tissue | Observation | 30 Day (n = 6 animals, 11 airways) | 365 Day (n = 5 animals, 10 airways) | 640 Day (n = 8 animals, 16 airways) |
|---|---|---|---|---|
Bronchial Epithelium | Necrosis | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 |
Acute Inflammation | 0.5 ± 0.2 | 0.2 ± 0.1 | 0.0 ± 0.0 | |
Chronic Inflammation | 0.5 ± 0.2 | 0.2 ± 0.1 | 0.1 ± 0.1 | |
Fibrosis | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | |
Bronchial Wall | Necrosis | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 |
Acute Inflammation | 0.5 ± 0.2 | 0.1 ± 0.1 | 0.0 ± 0.0 | |
Chronic Inflammation | 1.7 ± 0.2 | 1.2 ± 0.1 | 1.1 ± 0.1 | |
Fibrosis | 0.5 ± 0.2 | 0.4 ± 0.1 | 0.3 ± 0.1 | |
Bronchial Cartilage | Necrosis | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 |
Acute Inflammation | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | |
Chronic Inflammation | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | |
Fibrosis | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | |
Alveolar Parenchyma | Necrosis | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 |
Acute Inflammation | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | |
Chronic Inflammation | 1.0 ± 0.0 | 1.0 ± 0.0 | 1.0 ± 0.0 | |
Fibrosis | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | |
Hyperplasia | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | |
Metaplasia | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | |
Airway Ectasia | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 |