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Table 1 Histochemical semi-quantitative evaluation of proximal location to treatment site. Hematoxylin-eosin staining was used to evaluate the structural changes. All sections were evaluated on semi-quantitative 1–4 point scale. Values are mean ± SEM

From: Targeted lung denervation in sheep: durability of denervation and long-term histologic effects on bronchial wall and peribronchial structures

Tissue Observation 30 Day
(n = 6 animals, 11 airways)
365 Day
(n = 5 animals, 10 airways)
640 Day
(n = 8 animals, 16 airways)
Bronchial Epithelium Necrosis 0.0 ± 0.0 0.0 ± 0.0 0.0 ± 0.0
Acute Inflammation 0.5 ± 0.2 0.2 ± 0.1 0.0 ± 0.0
Chronic Inflammation 0.5 ± 0.2 0.2 ± 0.1 0.1 ± 0.1
Fibrosis 0.0 ± 0.0 0.0 ± 0.0 0.0 ± 0.0
Bronchial Wall Necrosis 0.0 ± 0.0 0.0 ± 0.0 0.0 ± 0.0
Acute Inflammation 0.5 ± 0.2 0.1 ± 0.1 0.0 ± 0.0
Chronic Inflammation 1.7 ± 0.2 1.2 ± 0.1 1.1 ± 0.1
Fibrosis 0.5 ± 0.2 0.4 ± 0.1 0.3 ± 0.1
Bronchial Cartilage Necrosis 0.0 ± 0.0 0.0 ± 0.0 0.0 ± 0.0
Acute Inflammation 0.0 ± 0.0 0.0 ± 0.0 0.0 ± 0.0
Chronic Inflammation 0.0 ± 0.0 0.0 ± 0.0 0.0 ± 0.0
Fibrosis 0.0 ± 0.0 0.0 ± 0.0 0.0 ± 0.0
Alveolar Parenchyma Necrosis 0.0 ± 0.0 0.0 ± 0.0 0.0 ± 0.0
Acute Inflammation 0.0 ± 0.0 0.0 ± 0.0 0.0 ± 0.0
Chronic Inflammation 1.0 ± 0.0 1.0 ± 0.0 1.0 ± 0.0
Fibrosis 0.0 ± 0.0 0.0 ± 0.0 0.0 ± 0.0
Hyperplasia 0.0 ± 0.0 0.0 ± 0.0 0.0 ± 0.0
Metaplasia 0.0 ± 0.0 0.0 ± 0.0 0.0 ± 0.0
Airway Ectasia 0.0 ± 0.0 0.0 ± 0.0 0.0 ± 0.0