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Fig. 5 | Respiratory Research

Fig. 5

From: Targeted lung denervation in sheep: durability of denervation and long-term histologic effects on bronchial wall and peribronchial structures

Fig. 5

Histopathological analysis at 30 days (n = 6 animals, 11 airways), 365 days (n = 5 animals, 10 airways), and 640 (n = 8 animals, 16 airways) of the alveolar parenchyma. Data are presented as mean ± SEM. *p < 0.05 vs 30 day time point, **p < 0.001 vs 30 day timepoint, † p < 0.05 365 vs. 640 day time point, ‡ p < 0.001 365 vs 640 day time point. a Semi-quantitative analysis of Alveolar parenchyma for necrosis (black bars), acute inflammation (open bars), chronic inflammation (diagonal stripe bars) and fibrosis (horizontal stripe bars). A small volume of alveolar parenchyma demonstrates tissue related effects of TLD therapy. b Semi-quantitative analysis of Alveolar parenchyma for hyperplasia (black bars), metaplasia (open bars) and ectasia (diagonal stripe bars). A small volume of alveolar parenchyma demonstrates tissue related effects of TLD therapy

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