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Fig. 4 | Respiratory Research

Fig. 4

From: MiR-223 plays a protecting role in neutrophilic asthmatic mice through the inhibition of NLRP3 inflammasome

Fig. 4

MCC950 suppressed the activation of NLRP3 and reduced pulmonary expression of caspase-1, IL-1β and IL-18 in miR-223−/− mice. a Proteins expression of NLRP3, ASC, caspase-1, pro-caspase-1 and GAPDH were measured by western blot after treatment. Representative immunoblot from three independent mice. b Proteins expression of IL-1β, pro-IL-1β, IL-18, pro-IL-18 and GAPDH were measured by western blot after treatment. Representative immunoblot from three independent mice. n = 6–8 mice/group; statistical significance was determined by ANOVA. c Genes expression of NLRP3, ASC, caspase-1, IL-1β and IL-18 were determined by quantitative PCR after treatment. n = 6–8 mice/group; statistical significance was determined by ANOVA. All data were expressed as mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001

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