Table 1 The model of acute lung diseases in the various animal species and treatment using the MSCs
From: Mesenchymal stem/stromal cells: the therapeutic effects in animal models of acute pulmonary diseases
| Â | The method of inflammation | The causative agent of inflammation | Animal species | The method of cell transplantation | Dose of the cell | Source of the cell | Type of the cell |
|---|---|---|---|---|---|---|---|
[30] | Intratracheal | LPS | Mice | Intravenous | 2.5 × 105 | Bone marrow of mice | MSCs |
[53] | Intrperitoneal | LPS | Mice | Intravenous | 5 × 105 | Bone marrow of mice | MSCs |
[28] | Intratracheal | LPS | Mice | Intratracheal | 7.5 × 105 | Bone marrow of mice | MSCs |
[54] | Intratracheal | E.coli | Mice | Intratracheal | 106 | Bone marrow of humman | MSCs |
Intravenous | LPS | Rat | Intravenous | 106 | Bone marrow of rat | MSCs | |
[56] | Intratracheal | LPS | Mice | Intratracheal | 106 | Umbilical cord of humman | MSCs |
[57] | Intratracheal | E.coli | Mice | Intratracheal | 105 | Umbilical cord of humman | MSCs |
[58] | Aspiration | LPS | Mice | Aspiration | 5 × 105 | Bone marrow of humman | MSCs |
[50] | Intrperitoneal | LPS | Mice | Intravenous | 5 × 105 | Umbilical cord of humman | MSCs |
[59] | Intratracheal | E.coli | Mice | Intratracheal | 7.5 × 105 | Bone marrow of mice | MSCs |
[60] | Intratracheal | LPS | Rat | Intrapleural | 106 | Bone marrow of rat | MSCs |
[51] | Intravenous | Oleic acid | Rat | Intravenous | 2 × 105 | Bone marrow of rat | MSCs |
[61] | Intratracheal | LPS | Mice | Intravenous | 5 × 105 | Bone marrow of mice | MSCs |
[38] | Intratracheal | LPS | Mice | Intratracheal | 2.5 × 105 | Bone marrow of mice | MSCs |
[62] | Intratracheal or Intrperitoneal | LPS | Mice | Intravenous | 105 | Bone marrow of mice | MSCs |
[63] | Ventilation | Ventilator | Rat | Intratracheal or Intravenous | 4 × 105 | Bone marrow of rat | MSCs |
Intranasal | LPS | Mice | Intravenous | 106 | Adipose tissue of humman | MSCs | |
[66] | Intratracheal | LPS | Mice | Intravenous | 5 × 105 | Bone marrow of mice | MSCs |
[67] | Intratracheal | E.coli | Mice | Intravenous | 5 × 105 | Bone marrow of mice | MSCs |
[68] | Intrperitoneal | LPS | Mice | Intravenous | 5 × 105 | Bone marrow of mice | MSCs |
[36] | Intratracheal | Smoke | Sheep | Intravenous | 10 × 106 | Bone marrow of humman | MSCs |
[69] | Intratracheal | LPS | Mice | Intravenous | 5 × 105 | Bone marrow of mice | MSCs |
[70] | Intrperitoneal | LPS | Mice | Intravenous | 5 × 105 | Bone marrow of mice | MSCs |
[71] | Intratracheal | LPS | Mice | Intratracheal | 7.5 × 105 | Bone marrow and embryonic of human | MSCs |
[72] | Intratracheal | E.Coli | Rat | Intratracheal | 2 × 106 5 × 106 1 × 107 2 × 107 | Bone marrow of human | MSCs |
[52] | Intranasal | H9N2 avian influenza virus | Mice | Intravenous | 105 | Bone marrow of mice | MSCs |
[48] | Aspiration | Stomach contents | Rat | Intravenous | 5 × 106 | Bone marrow of mice | MSCs |
[27] | Intratracheal | LPS | Mice | Intravenous | 0.5 × 106 | Umbilical cord of human | MSCs |
[37] | Intravenous | Oleic acid | Pig | Intravenous | 2 × 106 | Bone marrow of human | MSCs |
Intratracheal | LPS | Mice | Intravenous | 106 | Menstrual blood | MSCs | |
[74] | Intratracheal | LPS | Mice | retro-orbital injection | 5 × 105 | Adipose tissue of mice | MSCs |
[31] | Intratracheal | LPS | Sheep | Intratracheal | 5 × 107 | Bone marrow of sheep | MSCs |
[5] | Intratracheal | LPS | Rabbit | Intratracheal | 107 | Bone marrow of rabbit | MSCs |