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Table 1 The model of acute lung diseases in the various animal species and treatment using the MSCs

From: Mesenchymal stem/stromal cells: the therapeutic effects in animal models of acute pulmonary diseases

 The method of inflammationThe causative agent of inflammationAnimal speciesThe method of cell transplantationDose of the cellSource of the cellType of the cell
[30]IntratrachealLPSMiceIntravenous2.5 × 105Bone marrow of miceMSCs
[53]IntrperitonealLPSMiceIntravenous5 × 105Bone marrow of miceMSCs
[28]IntratrachealLPSMiceIntratracheal7.5 × 105Bone marrow of miceMSCs
[54]IntratrachealE.coliMiceIntratracheal106Bone marrow of hummanMSCs
[49, 55]IntravenousLPSRatIntravenous106Bone marrow of ratMSCs
[56]IntratrachealLPSMiceIntratracheal106Umbilical cord of hummanMSCs
[57]IntratrachealE.coliMiceIntratracheal105Umbilical cord of hummanMSCs
[58]AspirationLPSMiceAspiration5 × 105Bone marrow of hummanMSCs
[50]IntrperitonealLPSMiceIntravenous5 × 105Umbilical cord of hummanMSCs
[59]IntratrachealE.coliMiceIntratracheal7.5 × 105Bone marrow of miceMSCs
[60]IntratrachealLPSRatIntrapleural106Bone marrow of ratMSCs
[51]IntravenousOleic acidRatIntravenous2 × 105Bone marrow of ratMSCs
[61]IntratrachealLPSMiceIntravenous5 × 105Bone marrow of miceMSCs
[38]IntratrachealLPSMiceIntratracheal2.5 × 105Bone marrow of miceMSCs
[62]Intratracheal or IntrperitonealLPSMiceIntravenous105Bone marrow of miceMSCs
[63]VentilationVentilatorRatIntratracheal or Intravenous4 × 105Bone marrow of ratMSCs
[64, 65]IntranasalLPSMiceIntravenous106Adipose tissue of hummanMSCs
[66]IntratrachealLPSMiceIntravenous5 × 105Bone marrow of miceMSCs
[67]IntratrachealE.coliMiceIntravenous5 × 105Bone marrow of miceMSCs
[68]IntrperitonealLPSMiceIntravenous5 × 105Bone marrow of miceMSCs
[36]IntratrachealSmokeSheepIntravenous10 × 106Bone marrow of hummanMSCs
[69]IntratrachealLPSMiceIntravenous5 × 105Bone marrow of miceMSCs
[70]IntrperitonealLPSMiceIntravenous5 × 105Bone marrow of miceMSCs
[71]IntratrachealLPSMiceIntratracheal7.5 × 105Bone marrow and embryonic of humanMSCs
[72]IntratrachealE.ColiRatIntratracheal2 × 106
5 × 106
1 × 107
2 × 107
Bone marrow of humanMSCs
[52]IntranasalH9N2 avian influenza virusMiceIntravenous105Bone marrow of miceMSCs
[48]AspirationStomach contentsRatIntravenous5 × 106Bone marrow of miceMSCs
[27]IntratrachealLPSMiceIntravenous0.5 × 106Umbilical cord of humanMSCs
[37]IntravenousOleic acidPigIntravenous2 × 106Bone marrow of humanMSCs
[35, 73]IntratrachealLPSMiceIntravenous106Menstrual bloodMSCs
[74]IntratrachealLPSMiceretro-orbital injection5 × 105Adipose tissue of miceMSCs
[31]IntratrachealLPSSheepIntratracheal5 × 107Bone marrow of sheepMSCs
[5]IntratrachealLPSRabbitIntratracheal107Bone marrow of rabbitMSCs