Longitudinal functional changes with clinically significant radiographic progression in idiopathic pulmonary fibrosis: are we following the right parameters?

Table 2 Univariate regression analysis: predictors of lung transplant-free survival after the 2nd HRCT

Variable	Hazard ratio (C.I.)	p value
Age (years)	1.01 (0.98–1.05)	n.s.
Gender (male)	1.18 (0.65–2.24)	n.s.
BMI (kg/m²)	0.96 (0.90–1.01)	n.s.
Baseline HRCT fibrosis score	1.03 (1.01–1.06)	0.0057
HRCT fibrosis score change > 7%	2.10 (1.23–3.62)	0.0070
Baseline FVC	0.98 (0.97–0.99)	0.0126
FVC change ≥ 5%	2.13 (1.20–3.92)	0.0091
Baseline TLC	0.97 (0.95–0.99)	0.0081
TLC change ≥ 5%	0.99 (0.96–1.02)	n.s.
Baseline DLCO	0.94 (0.94–0.98)	< 0.0001
DLCO change ≥ 5%	1.31 (0.66–2.78)	n.s.

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