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Fig. 3 | Respiratory Research

Fig. 3

From: Prolonged Scar-in-a-Jar: an in vitro screening tool for anti-fibrotic therapies using biomarkers of extracellular matrix synthesis

Fig. 3

TGF-β1 induced collagen cross-linking which could be modulated by a LOX inhibitor. Levels of type I collagen cross-linking (αCTX-I) were assessed in collagenase-cleaved matrix produced by lung fibroblasts on day 12. Fibroblasts were cultured without stimulation (control), with TGF-β1 alone or with TGF- β1 and the pan-lysyl oxidase (LOX) inhibitor beta-aminopropionitrile (BAPN). Data are shown as mean ± SD of 4 replicates and analyzed by student’s t-test comparing TGF- β1 to control or TGF-β1 + BAPN. **P < 0.01; ****P < 0.0001

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Respiratory Research

ISSN: 1465-993X

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