Table 2 Transcription factors (TF) underlying the co-expressed gene modules correlated with PM exposure (“cyan”, “brown”, “blue” and “turquoise”). TFs of which the binding motifs are significantly overrepresented in the co-expressed gene modules (FDR < 0.1); or the target genes are overrepresented in the eigen genes of each module (q-value < 0.05) are listed along with the KEGG pathways enriched (FDR < 0.05) in each module

cyan

Nrf2(bZIP); NFkB-p65(RHD); n-Myc (bHLH); PIF4(bHLH); RAR:RXR (NR); IRF (bZIP,IRF)/Th17-BatF

NFKB1, RELA, JUN, NFIC, CEBPB, REL, CEBPD, SP1, CTNNB1, CDX1, STAT1, DLX1, STAT6, RELB, STAT3, DLX2, CEBPG, BCL6, PDX1, TFAP2A, STAT2, GATA4, JUNB, GATA1, JUND, CREB1, YY1, FOS, LEF1

Viral protein interaction with cytokine and cytokine receptor; IL-17 signaling pathway; Chemokine signaling pathway; Cytokine-cytokine receptor interaction; Salmonella infection; Rheumatoid arthritis; TNF signaling pathway; Fluid shear stress and atherosclerosis; Tuberculosis; NF-kappa B signaling pathway; AGE-RAGE signaling pathway in diabetic complications

brown

HOXA2(Homeobox); Hoxb4(Homeobox); STAT4(Stat);Pax7(Paired,Homeobox); E2A(bHLH); Stat3(Stat); STAT6(Stat)

MYC, SP1, TP53, STAT1, CEBPA, STAT3, HOXD3

PD-L1 expression and PD-1 checkpoint pathway in cancer

blue

FOXP1(Forkhead); Fli1(ETS); GABPA (ETS); GATA3(Zf);RUNX-AML (Runt); E2A(bHLH); ox2(HMG); ETS1(ETS); Eomes(T-box)

MYC, TFAP2A, SP1, ETS1, SPI1, GLI2, USF1, SP2, RELA, SP3, ELK1, POU2F2, REL, STAT3, POU1F1, ETV4, RELB, FOXO3, NFKB1, USF2, RUNX1, FOXO1, E2F1, CTNNB1, MYB, E2F6, MYBL2, RARA, GLI1, PPARD, JUN, RARG, PAX6, NFYA, TP53

Viral protein interaction with cytokine and cytokine receptor; ErbB signaling pathway; Epithelial cell signaling in Helicobacter pylori infection

turquoise

Fli1(ETS), ETS1(ETS); ELF1(ETS); Etv2(ETS); EABPA (ETS); Ets1-distal (ETS); RUNX (ETS,Runt)

CREB1, RBPJ, SP1, MYC, ATF1, CREBBP, SPI1, NFKB1, RELA, SREBF2, SREBF1, TP53, ETV4, E2F1, EGR1, FOXO1, NOTCH1, TFAP2A, YY1, BRCA1, BCL3, ETS1, TCF7L2, USF2, ATF6, JUN, STAT3, ESR1, CREM, PPARA, SMAD1, E2F6, FOXO3, PPARG, WT1, NFATC2, FLI1, RFX1, EGR4, OLIG1, FOXP1, CEBPB, PPARD, CTNNB1, ELK1, STAT5B, IRF9, STAT5A, ATF2, NFYA, GLI2, AR, USF1, STAT1, RELB, ID1, MYBL1, POU2F2, SMAD3, SMAD2, E2F4, ERG, FOXH1, CEBPA, REL, NFIC, ARNT, FEV, POU1F1, SP3, HOXA5, CEBPE, RARB, FOXO4, MYB, NFIA, NFATC1, SOX10, RARA, NR2F2, MITF, GABPA, HBP1, RARG, STAT2, SMAD4, HIF1A, NR1H2, NR1H3, TCF7, RUNX2, ATF4, NFE2L2, TBP, HNF4A, JUNB, NR2F1, CEBPD, GLI1, GATA1

Lysine degradation; RNA degradation; N-Glycan biosynthesis; Ubiquitin mediated proteolysis; Valine, leucine and isoleucine degradation; Spliceosome; RNA transport; Hepatitis C; Propanoate metabolism; Cytosolic DNA-sensing pathway