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Table 3 Metabolite annotation and pathway enrichment analysis using Mummichog for negative ion m/z features present in the native and allograft BAL fluid. * P < 0.05, Native vs Allograft samples with less enrichment of these pathways. Fischer’s Exact test was used for comparison and generation of enrichment P values. P-values for all pathways were then modeled as a Gamma distribution and then adjusted for the permutations

From: Differences in airway microbiome and metabolome of single lung transplant recipients

PathwaysPathway SizeAdjusted P Value
Purine Metabolism220.001
Methionine and Cysteine Metabolism130.002
Denovo-Fatty acid biosynthesis100.002
Fatty acid activation70.003
Vitamin B5-CoA biosynthesis70.003
Aspartate and Aspargine Metabolism210.003
Alanine and Aspartate Metabolism50.005
Arginine and Proline Metabolism90.006
Drug Metabolism CYP 450330.008
Saturated fatty acid beta-oxidation20.008
Phosphatidylinositol Phosphate Metabolism60.009
TCA Cycle30.01
Alkaloid Biosynthesis II30.01
Urea cycle200.01
Pyrimidine Metabolism130.03
Dynorphin Metabolism40.03
Omega 3 Fatty acid Metabolism40.03
COA Metabolism40.03
Fatty acid Metabolism40.03
Vitamin E Metabolism270.03
Linoleate Metabolism90.03