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Table 3 Metabolite annotation and pathway enrichment analysis using Mummichog for negative ion m/z features present in the native and allograft BAL fluid. * P < 0.05, Native vs Allograft samples with less enrichment of these pathways. Fischer’s Exact test was used for comparison and generation of enrichment P values. P-values for all pathways were then modeled as a Gamma distribution and then adjusted for the permutations

From: Differences in airway microbiome and metabolome of single lung transplant recipients

Pathways

Pathway Size

Adjusted P Value

Purine Metabolism

22

0.001

Methionine and Cysteine Metabolism

13

0.002

Denovo-Fatty acid biosynthesis

10

0.002

Fatty acid activation

7

0.003

Vitamin B5-CoA biosynthesis

7

0.003

Aspartate and Aspargine Metabolism

21

0.003

Alanine and Aspartate Metabolism

5

0.005

Arginine and Proline Metabolism

9

0.006

Drug Metabolism CYP 450

33

0.008

Saturated fatty acid beta-oxidation

2

0.008

Phosphatidylinositol Phosphate Metabolism

6

0.009

TCA Cycle

3

0.01

Alkaloid Biosynthesis II

3

0.01

Urea cycle

20

0.01

Pyrimidine Metabolism

13

0.03

Dynorphin Metabolism

4

0.03

Omega 3 Fatty acid Metabolism

4

0.03

COA Metabolism

4

0.03

Fatty acid Metabolism

4

0.03

Vitamin E Metabolism

27

0.03

Linoleate Metabolism

9

0.03