Skip to main content

Table 3 Metabolite annotation and pathway enrichment analysis using Mummichog for negative ion m/z features present in the native and allograft BAL fluid. * P < 0.05, Native vs Allograft samples with less enrichment of these pathways. Fischer’s Exact test was used for comparison and generation of enrichment P values. P-values for all pathways were then modeled as a Gamma distribution and then adjusted for the permutations

From: Differences in airway microbiome and metabolome of single lung transplant recipients

Pathways Pathway Size Adjusted P Value
Purine Metabolism 22 0.001
Methionine and Cysteine Metabolism 13 0.002
Denovo-Fatty acid biosynthesis 10 0.002
Fatty acid activation 7 0.003
Vitamin B5-CoA biosynthesis 7 0.003
Aspartate and Aspargine Metabolism 21 0.003
Alanine and Aspartate Metabolism 5 0.005
Arginine and Proline Metabolism 9 0.006
Drug Metabolism CYP 450 33 0.008
Saturated fatty acid beta-oxidation 2 0.008
Phosphatidylinositol Phosphate Metabolism 6 0.009
TCA Cycle 3 0.01
Alkaloid Biosynthesis II 3 0.01
Urea cycle 20 0.01
Pyrimidine Metabolism 13 0.03
Dynorphin Metabolism 4 0.03
Omega 3 Fatty acid Metabolism 4 0.03
COA Metabolism 4 0.03
Fatty acid Metabolism 4 0.03
Vitamin E Metabolism 27 0.03
Linoleate Metabolism 9 0.03