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Table 2 Pearson’s r correlations and determination coefficients (R2) between continuous CT metrics of emphysema (%LAA-950insp and %pLDA) or airway disease (% fLDA and AWTPi10) and functional parameters

From: Validation of a method to assess emphysema severity by spirometry in the COPDGene study

 

ESI

FEV1

FEV1/FVC

r

R2

p

r

R2

p

r

R2

p

%LAA-950inspa

0.80

0.64

<.001

−0.60

0.36

<.001

−0.75

0.56

<.001

%pLDAb

0.82

0.67

<.001

−0.63

0.40

<.001

−0.74

0.55

<.001

%fLDAb

0.59

0.35

<.001

−0.58

0.34

<.001

−0.71

0.50

<.001

AWTPi10a

0.17

0.03

<.001

−0.34

0.12

<.001

−0.16

0.03

<.001

  1. Legend: AWTPi10 = Average wall thickness of bronchi with an internal perimeter of 10 mm, %fLDA = percentage of functional low density area, %LAA-950insp = percentage of lung attenuation area with values <−950 Hounsfield Units at inspiratory CT scan, %pLDA = percentage of persistent low density area, a parameters calculated by using Apollo (VIDA), b parameters calculated by using Imbio