Fig. 4

Pathway analysis reveals the Phenylalanine pathway to be one of the most altered pathways in ARDS patients. a Pathway analysis uncovered the altered pathways in ARDS patients vs healthy controls. b Pathway analysis uncovered the altered pathways in the survivors vs non-survivors of ARDS. All matched pathways were shown according to P values from pathway enrichment analysis (y-axis) and all pathway impact values were according to pathway topology analysis (x-axis). The color and size of each circle are based on P values and pathway impact values, respectively. The deeper the red of the nod, the more significant alteration of the pathway is observed. Small P value and big pathway impact circles indicate that the pathway is greatly influenced. c The pathways that are altered between ARDS and healthy controls (pink circle) or between survivors and non-survivors (blue circle). The pathways in the cross area were identified in both groups. d Schematic diagram of metabolic pathway networks. The metabolites involved in the selected pathways (P < 0.05,impact factor > 0) altered between the survivors and the non-survivors were marked in different colors. Light blue means those metabolites are not in my data and are used as background for enrichment analysis; red (P < 0.05) and yellow (P > 0.05) means the metabolites are upregulated in the survivors deep green (P < 0.05) and light green (P > 0.05) mean that the metabolites are downregulated in survivors with different levels of significance. The metabolites in the box belong to the same pathway