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Fig. 7 | Respiratory Research

Fig. 7

From: MyD88 regulates a prolonged adaptation response to environmental dust exposure-induced lung disease

Fig. 7

An airway inflammatory adaptive response following ODE rechallenge in WT mice after a 4 week recovery from repetitive exposures with minimal responsiveness observed in MyD88 KO mice. WT and MyD88 KO mice were repetitively exposed to saline or ODE for 3 weeks followed by a 4 week rest/recovery phase and then subsequently rechallenged once with saline or ODE. Scatter dot plots demonstrate mean with standard error bars with treatment groups denoted as S-S (saline repeated exposure-saline rechallenge), O-S (ODE repeated exposure-saline rechallenge), S-O (saline repeated exposure-ODE rechallenge), O-O (ODE repeated exposure-ODE rechallenge). Panel a: Total cells, neutrophils, macrophages, and lymphocytes in BALF. Panel b: Proinflammatory cytokines/chemokines quantified in cell-free BALF. Panel c: Mediator levels quantified in cell-free lung homogenates. Panel d: Serum IgE levels. Statistical significance (#p < 0.05; ##p < 0.01; ###p < 0.001) vs. saline or denoted by line. N = 4 mice group (2 female/2 male)

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