Responsiveness and minimal clinically important difference of SGRQ-I and K-BILD in idiopathic pulmonary fibrosis

Respiratory Research

Table 2 Correlations between changes in SGRQ-I or K-BILD domains and changes in anchors from baseline to 12 months

	GRCS	ΔSOBQ	ΔSGRQ	ΔFVC%	ΔDLCO%	Δ6MWD
ΔSGRQ-I Total	−0.57	0.60	0.94	−0.21	−0.17	− 0.49
ΔSGRQ-I Symptoms	−0.44	0.39	0.54	−0.25	−0.05	− 0.33
ΔSGRQ-I Activities	−0.47	0.44	0.68	−0.21	−0.18	− 0.29
ΔSGRQ-I Impacts	−0.46	0.53	0.87	−0.09	−0.15	− 0.47
ΔK-BILD Total	0.49	−0.46	−0.63	0.20	0.19	0.28
ΔK-BILD Psychological	0.44	−0.38	−0.56	0.17	0.09	0.31
ΔK-BILD Breathlessness and activities	0.38	−0.47	−0.63	0.19	0.30	0.31
ΔK-BILD Chest symptoms	0.33	−0.26	−0.42	0.18	0.11	0.12

Δ: Change from baseline to 12 months; SGRQ-I IPF-specific version of the Saint George’s Respiratory Questionnaire, K-BILD King’s Brief Interstitial Lung Disease questionnaire, CI Confidence interval, GRCS Global rating of change scales, SOBQ University of California San Diego Shortness of Breath questionnaire, SGRQ Saint George’s Respiratory Questionnaire, FVC% Forced vital capacity % predicted, DLCO% Diffusing capacity of the lung for carbon monoxide % predicted, 6MWD Distance walked during the 6-min walk test

ISSN: 1465-993X