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Fig. 8 | Respiratory Research

Fig. 8

From: Inhibition of microRNA-451 is associated with increased expression of Macrophage Migration Inhibitory Factor and mitigation of the cardio-pulmonary phenotype in a murine model of Bronchopulmonary Dysplasia

Fig. 8

Effect of a miR-451 inhibitor on the expression of FOXO3 and YWHAZ. a Representative western blot showing the expression of the transcription factor forkhead box O3 (FOXO3) in both the nuclear phosphorylated form (FOXO3-P) and total (FOXO3) with β-actin serving as a control. b and c Quantification of FOXO3-P and FOXO3 expression relative to β-actin. Columns are representative of values ± SEM obtained from a minimum of 4 different animals. d Ratio of the normalized fraction of FOXO3-P to FOXO3, columns are representative of paired values ± SEM obtained from a minimum of 4 different animals. e Representative western blot showing the expression of the regulatory protein YWHAZ or 1–3-3-ζ with vinculin as a control. f Quantification of YWHAZ expression using densitometry with values relative to vinculin, each column is representative of the mean ± SEM of values obtained from a minimum of 4 different animals

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