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Fig. 4 | Respiratory Research

Fig. 4

From: Inhibition of microRNA-451 is associated with increased expression of Macrophage Migration Inhibitory Factor and mitigation of the cardio-pulmonary phenotype in a murine model of Bronchopulmonary Dysplasia

Fig. 4

Effect of an miR-451 inhibitor on lung morphometry indices and pulmonary arterial hypertension (PAH)-induced right ventricular hypertrophy (RVH). a Representative photomicrographs of murine lung tissue prepared with H&E stain obtained from NB WT RA, WT BPD, miR-451 inhibitor treated animals. b Alveolar size evaluated by mean chord length, septal thickness and radial alveolar counts are shown. Each column is representative of the mean ± SEM of measurements obtained from a minimum of 5 animals. The ratio of right ventricular wall thickness to the combined measurement of the left ventricular and interventricular septal wall thickness (RV/(LV + IVS)) is also shown as an indicator of PAH-induced RVH. Each column is representative of the mean ± SEM of measurements obtained from a minimum of 4 animals. NB: newborn, WT: wild type, RA: room air, BPD: bronchopulmonary dysplasia. * p < 0.05, ** p < 0.01, # p < 0.001, ## p < 0.0001

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Respiratory Research

ISSN: 1465-993X

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