The correlation between CYP4F2 variants and chronic obstructive pulmonary disease risk in Hainan Han population

Respiratory Research

Table 5 CYP4F2 haplotypes frequencies associated with COPD risk

Gene	SNP	Haplotype	Frequency		Unadjusted		Adjusted for Gender and Age
Gene	SNP	Haplotype	Case	Control	OR (95%CI)	p^a-value	OR (95%CI)	p^b-value
CYP4F2	rs3093203\|rs3093193\|rs12459936\|rs3093144\|rs3093110	GGCCG	0.941	0.881	2.15 (1.46–3.16)	p < 0.000	2.21 (1.36–3.60)	0.001
CYP4F2	rs3093203\|rs3093193\|rs12459936\|rs3093144\|rs3093110	GGCTA	0.139	0.162	0.83 (0.62–1.11)	0.201	1.02 (0.72–1.46)	0.896
CYP4F2	rs3093203\|rs3093193\|rs12459936\|rs3093144\|rs3093110	GCTCA	0.486	0.461	1.11 (0.91–1.36)	0.317	1.21 (0.94–1.55)	0.150
CYP4F2	rs3093203\|rs3093193\|rs12459936\|rs3093144\|rs3093110	GGCCA	0.979	0.997	0.14 (0.04–0.49)	0.002	0.09 (0.02–0.41)	0.002
CYP4F2	rs3093203\|rs3093193\|rs12459936\|rs3093144\|rs3093110	ACCCA	0.706	0.776	0.68 (0.54–0.86)	0.001	0.91 (0.68–1.23)	0.536
CYP4F2	rs3093203\|rs3093193\|rs12459936\|rs3093144\|rs3093110	GCCCA	0.998	0.975	16.22 (2.19–120.30)	0.006	15.18 (1.65–139.60)	0.016

95%CI: 95%Confidence interval, OR Odds ratio, SNP Single nucleotide polymorphism
p^a values were calculated by logistic regression analysis without adjusted
p^b values were calculated by logistic regression analysis after adjusted for gender and age

ISSN: 1465-993X