Table 4 Relationship of CYP4F2 gene polymorphisms and risk of COPD stratified by Smoking status
SNP | Model | Genotype | Smoking | Non-smoking | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
Control | Case | OR(95%CI) | p-value | Control | Case | OR(95%CI) | p-value | |||
rs3093203 | AA | 14 | 12 | 1 | 10 | 9 | 1 | |||
Codominant | AG | 80 | 54 | 1.01 (0.52–1.96) | 0.977 | 102 | 66 | 1.32 (0.80–2.16) | 0.277 | |
GG | 121 | 67 | 0.81 (0.22–3.02) | 0.758 | 179 | 73 | 1.08 (0.34–3.38) | 0.899 | ||
Dominant | AA | 14 | 12 | 1 | 10 | 9 | 1 | |||
AG-GG | 201 | 121 | 0.98 (0.52–1.85) | 0.949 | 281 | 139 | 1.29 (0.80–2.08) | 0.301 | ||
Recessive | AA-AG | 94 | 66 | 1 | 112 | 75 | 1 | |||
GG | 121 | 67 | 0.81 (0.23–2.91) | 0.747 | 179 | 73 | 0.96 (0.31–2.94) | 0.938 | ||
Log-additive | – | – | – | 0.95 (0.57–1.59) | 0.855 | – | – | 1.19 (0.8–1.79) | 0.396 | |
rs3093193 | GG | 16 | 4 | 1 | 23 | 7 | 1 | |||
Codominant | GC | 89 | 56 | 1.41 (0.74–2.72) | 0.298 | 123 | 58 | 0.78 (0.49–1.25) | 0.306 | |
CC | 110 | 87 | 2.07 (0.44–9.59) | 0.355 | 146 | 99 | 0.36 (0.13–1.02) | 0.054 | ||
Dominant | GG | 16 | 4 | 1 | 23 | 7 | 1 | |||
GC-CC | 199 | 143 | 1.46 (0.77–2.76) | 0.241 | 269 | 157 | 0.71 (0.45–1.11) | 0.134 | ||
Recessive | GG-GC | 105 | 60 | 1 | 146 | 65 | 1 | |||
CC | 110 | 87 | 1.76 (0.39–7.90) | 0.458 | 146 | 99 | 0.40 (0.15–1.11) | 0.078 | ||
Log-additive | – | – | – | 1.42 (0.83–2.45) | 0.204 | – | – | 0.69 (0.48–1.01) | 0.054 | |
rs3093110 | GG | 4 | 0 | 1 | 4 | 0 | 1 | |||
Codominant | GA | 41 | 16 | 0.61 (0.24–1.51) | 0.282 | 68 | 21 | 0.42 (0.23–0.78) | 0.006 | |
AA | 171 | 131 | – | – | 219 | 142 | – | – | ||
Dominant | GG | 4 | 0 | 1 | 4 | 0 | 1 | |||
GA-AA | 212 | 147 | 0.58 (0.24–1.43) | 0.237 | 287 | 163 | 0.40 (0.22–0.74) | 0.004 | ||
Recessive | GG-GA | 45 | 16 | 1 | 72 | 21 | 1 | |||
AA | 171 | 131 | – | – | 219 | 142 | – | – | ||
Log-additive | – | – | – | 0.57 (0.24–1.37) | 0.211 | – | – | 0.40 (0.22–0.73) | 0.003 | |