Table 2 Significant CYP4F2 variants associated with COPD susceptibility

rs3093203

AA

24

22

1

1

Codominant

AG

182

121

1.43 (1.05–1.93)

0.023

1.15 (0.78–1.69)

0.482

GG

300

140

1.97 (1.07–3.62)

0.031

0.99 (0.44–2.24)

0.985

Dominant

AA

206

143

1

1

AG-GG

300

140

1.49 (1.11–1.99)

0.008

1.13 (0.78–1.63)

0.526

Recessive

AA-AG

24

22

1

1

GG

482

261

1.69 (0.93–3.08)

0.084

0.94 (0.42–2.07)

0.869

Log-additive

–

–

–

1.41 (1.11–1.79)

0.004

1.07 (0.80–1.46)

0.646

rs3093193

GG

39

11

1

1

Codominant

GC

212

115

0.74 (0.55–1.00)

0.048

0.93 (0.65–1.34)

0.704

CC

256

187

0.39 (0.19–0.77)

0.007

0.49 (0.21–1.14)

0.099

Dominant

GG

251

126

1

1

GC-CC

256

187

0.69 (0.52–0.91)

0.010

0.86 (0.61–1.23)

0.421

Recessive

GG-GC

39

11

1

1

CC

468

302

0.44 (0.22–0.87)

0.018

0.51 (0.22–1.16)

0.108

Log-additive

–

–

–

0.69 (0.54–0.88)

0.002

0.82 (0.61–1.11)

0.197

rs3093110

GG

8

0

1

1

Codominant

GA

109

37

0.48 (0.32–0.72)

p < 0.000

0.46 (0.28–0.76)

0.002

AA

390

275

–

–

–

–

Dominant

GG

117

37

1

1

GA-AA

390

275

0.45 (0.30–0.67)

p < 0.000

0.44 (0.27–0.72)

0.001

Recessive

GG-GA

8

0

1

1

AA

499

312

–

–

–

–

Log-additive

–

–

–

0.44 (0.30–0.65)

p < 0.000

0.44 (0.27–0.72)

0.001