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Table 4 Association of emphysema with reactive hyperemia index and arterial stiffness

From: Endothelial dysfunction is not a predictor of outcome in chronic obstructive pulmonary disease

 

Univariate analysis

Multivariate analysisa

Beta-estimate ± SEM

P-value

Beta-estimate ± SEM

P-value

RHI

 Emphysema

0.034 ± 0.13

0.78

−0.05 ± 0.15

0.74

 Centrilobular emphysema

0.08 ± 0.19

0.70

0.10 ± 0.19

0.60

 Paraseptal emphysema

0.03 ± 0.06

0.68

0.04 ± 0.06

0.48

Arterial stiffness

 Emphysema

1.8 ± 3.8

0.64

3.2 ± 4.3

0.457

 Centrilobular emphysema

0.3 ± 5.0

0.95

−6.4 ± 5.1

0.210

 Paraseptal emphysema

4.7 ± 1.6

0.005

4.3 ± 1.5

0.006

  1. aModel adjusted for age, gender, body mass index, smoking status, pack years, FEV1, arterial hypertension, diabetes mellitus, and statin use