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Table 6 Sensitivity analyses: evaluation of different lengths of the latency period and a cohort age restriction, using time-dependent exposure and the recency-weighted duration of exposure metrics, with time to lung cancer as the outcome

From: Statin use and lung cancer risk in chronic obstructive pulmonary disease patients: a population-based cohort study

 

Multivariable Regression

HR

95% CI LL

95%CI UL

p-value

Latency Period

 None

  Time-Dependent Statin Exposurea

1.00

0.87

1.16

0.9698

  Recency-Weighted Duration of Useb

1.04

0.97

1.12

0.2754

 6 months

  Time-Dependent Statin Exposure

0.96

0.82

1.12

0.5808

  Recency-Weighted Duration of Use

1.00

0.92

1.08

0.9214

 1 yearc

  Time-Dependent Statin Exposure

0.85

0.73

1.00

0.05

  Recency-Weighted Duration of Use

0.85

0.77

0.93

0.0006

 2 years

  Time-Dependent Statin Exposure

0.62

0.52

0.73

< 0.0001

  Recency-Weighted Duration of Use

0.57

0.49

0.66

< 0.0001

Cohort (Age ≥ 65 years)

  Time-Dependent Statin Exposure

0.72

0.60

0.86

0.0004

  Recency-Weighted Duration of Use

0.78

0.70

0.87

< 0.0001

  1. aThis is the reference-case for the analysis. bThe recency-weighted duration of use exposure metric is presented because it was selected as the best model based on AIC values. cA one-year latency period was assumed in the primary analysis and is presented here for comparison purposes