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Table 4 Biological processes were identified from the mapped genes based on the IOW-ALSPAC consistent CpGs

From: Changes of DNA methylation are associated with changes in lung function during adolescence

Name of the Biological process

PRaw-value

PFDR -value

Hit in Query List

Positive regulation of RNA metabolic process

3.39E-05

2.93E-02

CELF4, INSIG1, PTCH1, RPS6KA4, ZNF304,RARA, IKBKB, BANP

Positive regulation of nucleobase-containing compound metabolic process

9.30E-05

2.93E-02

CELF4,INSIG1,PTCH1,RPS6KA4,ZNF304, RARA, IKBKB, BANP

Positive regulation of gene expression

1.16E-04

2.93E-02

CELF4, INSIG1, PTCH1, RPS6KA4, ZNF304, RARA, IKBKB, BANP

Interleukin-1-mediated signaling pathway

1.33E-04

2.93E-02

RPS6KA4, IKBKB

Positive regulation of nitrogen compound metabolic process

1.42E-04

2.93E-02

CELF4, INSIG1, PTCH1, RPS6KA4, ZNF304, RARA, IKBKB, BANP

Positive regulation of nucleic acid-templated transcription

2.30E-04

3.19E-02

INSIG1, PTCH1, RPS6KA4, ZNF304, RARA, IKBKB, BANP

Positive regulation of transcription, DNA-templated

2.30E-04

3.19E-02

INSIG1, PTCH1, RPS6KA4, ZNF304, RARA, IKBKB, BANP

Positive regulation of RNA biosynthetic process

2.47E-04

3.19E-02

INSIG1, PTCH1, RPS6KA4, ZNF304, RARA, IKBKB, BANP

  1. Note: The same biological processes were involved in the BAMSE cohort based on the CpGs identified BAMSE, although they did not survive multiple testing after controlling for FDR of 0.05
  2. Genes which were formatted in bold, involved in the biological processes in both ALSPAC and BMASE cohorts