From: Changes of DNA methylation are associated with changes in lung function during adolescence
IOW cohort | ||||||
---|---|---|---|---|---|---|
 | Sub cohort at age 10: Participants with lung function Mean ± SD | Study sample at age 10: Participants with lung function and DNA-M Mean ± SD | P- values | Sub cohort at age 18: Participants with lung function Mean ± SD | Study sample at age 18: Participants with lung function and DNA-M Mean ± SD | P-values |
Factors | n = 488 | n = 183 |  | n = 395 | n = 212 |  |
Males | ||||||
FEV1(L) | 2.05 ± 0.30 | 2.06 ± 0.29 | 0.477 | 4.62 ± 0.62 | 4.64 ± 0.62 | 0.621 |
FVC (L) | 2.35 ± 0.34 | 2.36 ± 0.33 | 0.813 | 5.35 ± 0.72 | 5.35 ± 0.73 | 0.930 |
FEV1/FVC | 0.88 ± 0.06 | 0.88 ± 0.06 | 0.651 | 0.87 ± 0.07 | 0.87 ± 0.07 | 0.904 |
Height (cm) | 139.00 ± 5.90 | 138.94 ± 5.95 | 0.893 | 177.83 ± 6.65 | 177.56 ± 6.87 | 0.568 |
BMI | 17.57 ± 2.52 | 17.65 ± 2.54 | 0.665 | 22.51 ± 3.72 | 22.64 ± 3.72 | 0.609 |
 | n(%) | n(%) |  | n(%) | n(%) |  |
Smokinga | ||||||
Non- smoker | – | – | – | 222 (56.20) | 119 (56.13) | 0.813 |
Current smoker | – | – |  | 93 (23.54) | 46 (21.70) |  |
Past smoker | – | – |  | 72 (18.23) | 44 (20.75) |  |
Missing | – | – |  | 8 (2.03) | 3 (1.42) |  |
Females | n = 492 | n = 137 |  | n = 443 | n = 241 |  |
FEV1(L) | 2.00 ± 0.29 | 2.01 ± 0.29 | 0.832 | 3.51 ± 0.45 | 3.53 ± 0.43 | 0.340 |
FVC (L) | 2.23 ± 0.33 | 2.24 ± 0.34 | 0.657 | 4.03 ± 0.53 | 4.04 ± 0.51 | 0.737 |
FEV1/FVC | 0.90 ± 0.06 | 0.90 ± 0.05 | 0.337 | 0.88 ± 0.07 | 0.87 ± 0.07 | 0.563 |
Height (cm) | 139.02 ± 6.43 | 139.22 ± 6.58 | 0.719 | 164.68 ± 6.17 | 165.08 ± 6.37 | 0.331 |
BMI | 18.74 ± 3.34 | 18.66 ± 3.41 | 0.789 | 23.84 ± 4.72 | 23.89 ± 4.61 | 0.870 |
 | n(%) | n(%) |  | n(%) | n(%) |  |
Smokinga | ||||||
Non- smoker | – | – | – | 240 (54.18) | 129 (53.53) | 0.979 |
Current smoker | – | – |  | 111 (25.06) | 61 (25.31) |  |
Past smoker | – | – |  | 87 (19.64) | 49 (20.33) |  |
Missing | – | – |  | 5 (1.13) | 2 (0.83) |  |