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Table 2 Characteristics of subjects with methylation data and lung function of IOW cohort, stratified by gender

From: Changes of DNA methylation are associated with changes in lung function during adolescence

IOW cohort

 

Sub cohort at age 10:

Participants with lung function

Mean ± SD

Study sample at age 10:

Participants with lung function and DNA-M Mean ± SD

P- values

Sub cohort at age 18:

Participants with lung function Mean ± SD

Study sample at age 18:

Participants with lung function and DNA-M Mean ± SD

P-values

Factors

n = 488

n = 183

 

n = 395

n = 212

 

Males

FEV1(L)

2.05 ± 0.30

2.06 ± 0.29

0.477

4.62 ± 0.62

4.64 ± 0.62

0.621

FVC (L)

2.35 ± 0.34

2.36 ± 0.33

0.813

5.35 ± 0.72

5.35 ± 0.73

0.930

FEV1/FVC

0.88 ± 0.06

0.88 ± 0.06

0.651

0.87 ± 0.07

0.87 ± 0.07

0.904

Height (cm)

139.00 ± 5.90

138.94 ± 5.95

0.893

177.83 ± 6.65

177.56 ± 6.87

0.568

BMI

17.57 ± 2.52

17.65 ± 2.54

0.665

22.51 ± 3.72

22.64 ± 3.72

0.609

 

n(%)

n(%)

 

n(%)

n(%)

 

Smokinga

Non- smoker

–

–

–

222 (56.20)

119 (56.13)

0.813

Current smoker

–

–

 

93 (23.54)

46 (21.70)

 

Past smoker

–

–

 

72 (18.23)

44 (20.75)

 

Missing

–

–

 

8 (2.03)

3 (1.42)

 

Females

n = 492

n = 137

 

n = 443

n = 241

 

FEV1(L)

2.00 ± 0.29

2.01 ± 0.29

0.832

3.51 ± 0.45

3.53 ± 0.43

0.340

FVC (L)

2.23 ± 0.33

2.24 ± 0.34

0.657

4.03 ± 0.53

4.04 ± 0.51

0.737

FEV1/FVC

0.90 ± 0.06

0.90 ± 0.05

0.337

0.88 ± 0.07

0.87 ± 0.07

0.563

Height (cm)

139.02 ± 6.43

139.22 ± 6.58

0.719

164.68 ± 6.17

165.08 ± 6.37

0.331

BMI

18.74 ± 3.34

18.66 ± 3.41

0.789

23.84 ± 4.72

23.89 ± 4.61

0.870

 

n(%)

n(%)

 

n(%)

n(%)

 

Smokinga

Non- smoker

–

–

–

240 (54.18)

129 (53.53)

0.979

Current smoker

–

–

 

111 (25.06)

61 (25.31)

 

Past smoker

–

–

 

87 (19.64)

49 (20.33)

 

Missing

–

–

 

5 (1.13)

2 (0.83)

 
  1. aActive smoking at age 10 years in the IOW Cohort was not identified
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Respiratory Research

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