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Table 2 Adjusted posterior median ratios of uncorrected VT (mL/cm3)

From: A positron emission tomography imaging study to confirm target engagement in the lungs of patients with idiopathic pulmonary fibrosis following a single dose of a novel inhaled αvβ6 integrin inhibitor

Parameter

Adjusted Median of Ratio

95% HPD CrI of Ratio

SD Logs of Ratio

Probability (True Ratio < 1.0)

PET1/Pre-dose

0.797

(0.578, 1.087)

0.1576

0.934

PET2/Pre-dose

1.154

(0.791, 1.647)

0.1779

0.175

PET2/PET1

1.446

(0.984, 2.083)

0.1868

0.030

  1. HPD Crl Highest posterior density credible interval; PET positron emission tomography; PET1 PET scan on day 1 at ~ 30 min post-dose (n = 5); PET2 PET scan on day 2 at ~ 24 h post-dose (n = 3)
  2. PET data from the placebo participants were included on plots for reference but were not included in the analysis
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Respiratory Research

ISSN: 1465-993X

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