Table 5 Elements of construct validity and external validity
Category | Items |
|---|---|
Animal species and strain (for mice) | Human lung preparation, mouse, rat, sheep, pig, rabbit, dog or others |
Animal age | Young, middle-aged, and mature, depending on species |
Animal gender | Male, female, both |
Comorbidity | Yes or no, type |
Model of acute lung injury | As defined in Table 1 |
Severity of lung injury | Lung injury score |
Intervention type | The drug, mode of administration and dose |
Timing of intervention regarding to acute lung injury induction | Before lung injury, 0 to 1, 1 to 6, and > 6 h after lung injury |
Type of control | Injured, non-injured |
Use of co-interventions | Resuscitation fluids, use of antibiotics, type of anesthesia, mechanical ventilation strategy |
Number of study centers | Single versus multi-center |