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Table 5 Elements of construct validity and external validity

From: Acute respiratory distress syndrome subphenotypes and therapy responsive traits among preclinical models: protocol for a systematic review and meta-analysis

Category Items
Animal species and strain (for mice) Human lung preparation, mouse, rat, sheep, pig, rabbit, dog or others
Animal age Young, middle-aged, and mature, depending on species
Animal gender Male, female, both
Comorbidity Yes or no, type
Model of acute lung injury As defined in Table 1
Severity of lung injury Lung injury score
Intervention type The drug, mode of administration and dose
Timing of intervention regarding to acute lung injury induction Before lung injury, 0 to 1, 1 to 6, and > 6 h after lung injury
Type of control Injured, non-injured
Use of co-interventions Resuscitation fluids, use of antibiotics, type of anesthesia, mechanical ventilation strategy
Number of study centers Single versus multi-center