Study characteristics
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DOI, Num ID (specific number ID for the purpose of the meta-analysis), title, author, year, country and journal of publication, country of study, mono/multicentric
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Study population (experimental model)
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Animal species or ex vivo model, age, gender, strain, weight, and comorbidity
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Type of acute lung injury model
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As defined in Table 1, with timing
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Intervention
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Type (see TableĀ 2), number, timing, mode of administration, dose
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Co-intervention
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Resuscitation fluids, antibiotics, mechanical ventilation parameters, mode of anesthesia, drugs, etc.
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Preclinical endpoints
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As defined in Table 3
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Risk of bias assessments (Cochrane risk of bias tool)
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Randomization, allocation, blinding and completeness of follow-up
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Quality of reporting of individual preclinical studies
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ARRIVE (Animal Research: Reporting of In Vivo Experiments) guidelines elements
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