Acute respiratory distress syndrome subphenotypes and therapy responsive traits among preclinical models: protocol for a systematic review and meta-analysis

Table 2 Predefined list of select therapies included in the meta-analysis

Class	Example of therapies
Interleukins	IL-10, IL-2
Cell therapy	MSCs, MSC-derived microvesicles
Adrenergic beta-agonists	Salbutamol, albuterol, sultanol, proventil
Growing factors	Fibroblast growing factors, keratinocyte growth factor, endothelial growth factor
RAGE modulators	Anti-RAGE antibody, recombinant soluble RAGE, gene knockout, endogenous secretory RAGE
Corticosteroids	Glucocorticoids, mineralocorticoids, 3-oxo steroid, 17-ketosteroids, domolene, cortifan, epicortisol, komed-hc, heb-cort, prednisone, encortone, panasol, deltacortisone, decortisyl, decortin, predeltin, orasone, prednidib, prednisone, dacortin, cortancyl, solupred, deltasone, pronisone, sterapred, encorton, panafcort, delta-dome, dehydrocortisone, prednisonum, lisacort, ultracorten, winpred, metacortandracin, meticorten, prednisolone, predate, prednisolone, di-adreson f, delta-1-hydrocortisone, prednisolonum, sterane, meti derm, metacortandralone, predonine
Anticoagulant agents	Heparin, antithrombin, plasminogen activator, fibrinolytic agents, tissue factor pathway inhibitor, lipoprotein-associated coagulation inhibitor, thrombin-thrombomodulin complex, thrombin receptor, activated protein C, drotrecogin alfa activated
Halogenated agents	Sevoflurane, desflurane, isoflurane

IL interleukin; MSCs mesenchymal stem (stromal) cells; RAGE receptor for advanced glycation end-products

ISSN: 1465-993X