Heme metabolism genes Downregulated in COPD Cachexia

Respiratory Research

Table 4 Gene Set Enrichment Analysis of Genes Associated with COPD Cachexia in COPDGene which replicated in ECLIPSE

Gene Set Name	N Genes in Set	N Genes Overlap	FDR p-value
GSE34205 RSV vs Flu INF Infant PBMC Up	200	7	3.27 × 10⁻¹⁰
Hallmark Heme Metabolism	200	6	4.50 × 10⁻⁸
Valk AML Cluster 7	28	3	0.00023
GSE34205 Healthy vs RSV INF Infant PBMC Down	200	4	0.00067
Chyla CBFA2T3 Targets Down	242	4	0.0011
Steiner Erythrocyte Membrane Genes	15	2	0.017
GO Heme Biosynthetic Process	20	2	0.025
Welch GATA1 Targets	22	2	0.025
PRC2 SUZ12 Up V1 Up	191	3	0.025
REACTOME Interaction Between L1 AND Ankyrins	23	2	0.025
GSE16522 Anti CD3CD28 Stim VS Unstim Memory CD8 T-Cell Up	199	3	0.025
Valk AML Cluster 8	26	2	0.025
GO Tetrapyrrole Biosynthetic Process	27	2	0.025
GO Heme Metabolic Process	29	2	0.029
GO Porphyrin Containing Compound Metabolic Process	36	2	0.041
Hofmann Cell Lymphoma Down	39	2	0.046

ISSN: 1465-993X