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Table 3 Results of the zero-inflated negative binomial regression of frequency of hospitalisations stratified in ILD-related and non-ILD-related

From: Hospitalisation patterns of patients with interstitial lung disease in the light of comorbidities and medical treatment – a German claims data analysis

  

Non-ILD related

ILD-related

Rate ratio

p-value

Rate ratio

p-value

Negative binomial model

 Sex

Male

Reference

 

Reference

 

Female

0.96

0.0009

0.91

<.0001

 Entity

SARC

Reference

 

Reference

 

IIP

1.23

<.0001

1.31

<.0001

OFI

1.36

<.0001

1.29

<.0001

DAI

1.43

<.0001

1.26

0.0002

PNE

1.25

<.0001

1.06

0.0945

RAP

1.63

<.0001

1.20

0.0036

EPP

1.43

<.0001

1.13

0.0007

HSP

1.08

0.0535

1.07

0.1265

CTD

2.17

<.0001

0.63

<.0001

 OSAS

If present in quarter of diagnosis

1.11

<.0001

1.09

0.0007

 Depression

If present in quarter of diagnosis

1.09

<.0001

1.04

0.0248

 Diabetes

If present in quarter of diagnosis

1.07

<.0001

1.16

<.0001

 GERD

If present in quarter of diagnosis

1.10

<.0001

1.00

0.7957

 COPD

If present in quarter of diagnosis

0.90

<.0001

1.27

<.0001

 CHD

If present in quarter of diagnosis

1.15

<.0001

1.19

<.0001

 Lung cancer

If present in quarter of diagnosis

2.04

<.0001

0.89

<.0001

 Pulmonary hypertension

If present in quarter of diagnosis

0.94

0.001

1.68

<.0001

 Number of comorbidities

If present in quarter of diagnosis

1.23

<.0001

1.07

<.0001

 Lung transplantation

If occured during observation period

1.83

<.0001

2.36

<.0001

 Immunosuppressive drugs

If treated during observation period

1.24

<.0001

1.24

<.0001

 Anti-fibrotic drugs

If treated during observation period

0.77

<.0001

2.12

<.0001

 Steroids

If treated during observation period

1.28

<.0001

1.95

<.0001

 Age (in years)

1.02

<.0001

1.00

0.2924

 Age square (in year)

1.00

<.0001

1.00

0.0055

 Time under observation (in quarters)

1.17

<.0001

1.09

<.0001

 Time under observation squared (in quarters)

1.00

<.0001

1.00

<.0001

Logistic model

 Age (in years)

1.06

<.0001

  

 Age square (in year)

1.00

<.0001

  

 Time under observation (in quarters)

1.07

0.0005

1.28

0.0404

 Time under observation squared (in quarters)

1.00

0.0008

  
  1. Significant estimates are printed in bold
  2. DAI Drug-Associated ILDs, CHD coronary heart disease, COPD chronic obstructive pulmonary disease, CTD Connective Tissue-associated ILD, EPP Eosinophilic Pneumonia, GERD Gastroesophageal Reflux Disease, HSP Hypersensitivity Pneumonitis, IIP Idiopathic Interstitial Pneumonia, ILD interstitial lung disease, OFI Other Fibrosing ILDs, PNE Pneumoconiosis, RAP Radiation-Associated Pneumonitis, SARC Sarcoidosis