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Fig. 1 | Respiratory Research

Fig. 1

From: Lung volume dependence of respiratory function in rodent models of diabetes mellitus

Fig. 1

Schemes summarizing the pretreatment strategies (a) and the experimental protocol (b). Forced oscillation measurements and blood gas analyzes were performed at three different positive end-expiratory pressures (0, 3, and 6 cmH2O: PEEP0, PEEP3, and PEEP6, respectively). Forced oscillation respiratory mechanics were assessed at a PEEP of 3 cmH2O during provocation tests with increasing doses (2–32 μg/kg/min) of methacholine (MCh) following the baseline measurement (BL). Abbreviations: DM1, model of type 1 diabetes; DM2, model of type 2 diabetes; C, control group; STZ, streptozotocin in mg/kg; FRC, measurement of functional residual capacity; PREP, animal preparations

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