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Table 3 Crude and adjusted hazard ratios (HR) of 5-year mortality from time since IPF diagnosis, for the significant baseline predictors at diagnosis, with redefined cut-points for age and TLCO categories defining the GAP indexb, estimated by Cox proportional hazards model

From: The European MultiPartner IPF registry (EMPIRE): validating long-term prognostic factors in idiopathic pulmonary fibrosis

 

n (%)

Crude HR

Adjusted HRa (95% CI)

Age at diagnosis

  ≥ 75 years

353 (22)

1.54

2.16 (1.61–2.89)

 65–74 years

730 (45)

1.16

1.34 (1.04–1.74)

  < 65 years

537 (33)

Reference

Reference

Men

1157 (71)

1.76

1.52 (1.16–1.97)

Predicted FVC

  < 50%

78 (5)

5.62

3.80 (2.53–5.70)

 50–75%

669 (41)

2.66

1.98 (1.55–2.54)

  > 75%

873 (54)

Reference

Reference

Predicted TLCO

  ≤ 55%

1106 (68)

4.63

3.22 (2.27–4.56)

  > 55%

514 (32)

Reference

Reference

  1. aAdjusted for all other predictors, concordance-index = 0.75
  2. b Scores based on magnitude of hazard ratios