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Table 2 Crude and adjusted hazard ratios (HR) of 5-year mortality from time since IPF diagnosis, for the significant baseline predictors at diagnosis, with categories defined by the GAP index, as estimated by the Cox proportional hazards model

From: The European MultiPartner IPF registry (EMPIRE): validating long-term prognostic factors in idiopathic pulmonary fibrosis

 

Number (%)

Crude HR

Adjusted HRa (95% CI)

Age at diagnosis

  > 65 years

1018 (63)

1.25

1.52 (1.14–2.03)

 61–65 years

274 (17)

0.99

1.01 (0.70–1.47)

  ≤ 60 years

328 (20)

Reference

Reference

Male sex

1157 (71)

1.76

1.51 (1.15–1.96)

FVC (% predicted)

  < 50%

78 (5)

5.62

3.45 (2.28–5.23)

 50–75%

669 (41)

2.66

1.89 (1.47–2.42)

  > 75%

873 (54)

Reference

Reference

TLCO (% predicted)

  ≤ 35%

419 (26)

6.22

3.52 (2.40–5.18)

 36–55%

687 (42)

3.90

3.05 (2.13–4.36)

  > 55%

514 (32)

Reference

Reference

Pulmonary hypertension

123 (8)

2.63

2.04 (1.46–2.86)

Lung cancer

19 (1)

3.47

2.55 (1.33–4.92)

Long-term oxygen therapy

327 (20)

2.35

1.49 (1.19–1.88)

  1. Abbreviations: FVC forced vital capacity, TLCO carbon monoxide transfer factor
  2. aAdjusted for one another, concordance index = 0.76