Fig. 6
Expression of NLRP3 in PH and CIH model. a. mRNA expression of NLRP3 in the lung in WT and SOD2−/+ mice under normal air and CIH condition. b. Measurement of histology score of IHC staining of NLRP3 in the lung in the four groups. c and e. IHC staining of NLRP3 in the lung in the four groups. Arrows were pointed to the pulmonary arteriole. The rectangular frame was amplified in the same times in the picture of c and e; d and f. Co-staining of CD11b and NLRP3 by immunofluorescence in the four groups. Blue represented DAPI. Red represented NLRP3. Green represented CD11b. The rectangular frame was amplified in the same times in the picture of d and f. CON: Wild type mice in the normal air condition. CIH: Chronic intermittent hypoxia. WT: wild type mice. SOD2−/+: knock-down of SOD2 gene heterozygous mice. N = 5. Comparisons between multiple groups were performed using ANOVA with the Bonferroni test. *p < 0.05, **p < 0.01, ***p < 0.001