Fig. 2
PH pressure detection and Echocardiography in WT and SOD2−/+ mice. a. Right ventricular systolic pressure (RVSP) measured by closed-chest puncture of the right ventricle (RV). b. Ratio of right ventricle to left ventricle plus septum in the four groups. c. Statistical analysis of right ventricle cross-sectional area (RVCSA). d. Representative enchocardiography of RV. e. Statistical analysis of thickness of RV. f. The representative view of PA in color Doppler mode, used to assess flow through the PA, was presented. g. The blood flow velocity of PA was measured by echocardiography. h. The representative enchocardiography of tricuspid annular plane systolic excursion (TAPSE) in the four groups. i. Data of TAPSE. CON: Wild type mice in the normal air condition. CIH: Chronic intermittent hypoxia. WT: wild type mice. SOD2−/+: knock-down of SOD2 gene heterozygous mice. N = 5. Comparisons between multiple groups were performed using ANOVA with the Bonferroni test. *p < 0.05, **p < 0.01, ***p < 0.001