Table 1 Physiological measurements in the control, CMV, NAVA, and PSV groups
From: Neurally adjusted ventilatory assist mitigates ventilator-induced diaphragm injury in rabbits
Time (hours) | Control | CMV | NAVA | PSV | p valuea | |
|---|---|---|---|---|---|---|
Body weight (kg) | NA | 2.6 [2.6–2.7] | 2.7 [2.5–2.7] | 2.8 [2.7–2.8] | 2.8 [2.5–2.8] | 0.21 |
Heart rate (bpm) | 0 | 138 [130–150] | 142 [126–157] | 116 [110–124] | 127 [126–150] | 0.36 |
6 | NA | 163 [140–200] | 138 [132–144] | 148 [145–158] | 0.43 | |
12 | NA | 180 [156–181] | 134 [130–160] | 144 [135–146] | 0.37 | |
Systolic blood pressure (mmHg) | 0 | 82 [80–90] | 85 [80–90] | 102 [95–105] | 84 [77–90] | 0.035 |
6 | NA | 85 [80–88] | 79 [79–100] | 80 [75–86] | 0.91 | |
12 | NA | 87 [80–91] | 86 [81–87] | 77 [70–88] | 0.69 | |
Diastolic blood pressure (mmHg) | 0 | 58 [58–60] | 70 [65–70] | 75 [72–82] | 68 [56–72] | 0.055 |
6 | NA | 60 [54–68] | 50 [50–63] | 58 [57–61] | 0.93 | |
12 | NA | 62 [60–71] | 59 [54–60] | 56 [45–59] | 0.29 | |
Body temperature (°C) | 0 | 38.8 [38.2–38.9] | 38.1 [37.4–38.2] | 38.5 [38.5–38.9] | 38.4 [38.4–38.5] | 0.19 |
6 | NA | 38.7 [38.1–39.0] | 38.5 [38.5–38.8] | 39.2 [38.7–39.7] | 0.39 | |
12 | NA | 39.0 [38.3–39.2] | 38.6 [38.2–39.3] | 39.4 [38.9–39.5] | 0.51 | |
PaO2/FIO2 | 0 | NA | 264 [244–275] | 251 [232–293] | 276 [275–285] | 0.74 |
6 | NA | 257 [209–258] | 271 [257–281] | 259 [257–261] | 0.37 | |
12 | NA | 255 [220–267] | 283 [268–303] | 253 [248–259] | 0.11 | |
PaCO2 (mmHg) | 0 | NA | 42 [39–50] | 37 [36–41] | 39 [37–45] | 0.48 |
6 | NA | 44 [41–48] | 39 [37–43] | 40 [38–46] | 0.36 | |
12 | NA | 43 [43–45] | 41 [38–41] | 45 [35–46] | 0.54 | |
Respiratory rate (rpm) | NA | 48 [38–60] | 40 [40–55] | 42 [35–51] | 45 [39–59] | 0.86 |
Peak inspiratory pressure (cmH2O) | NA | NA | 14.0 [12.9–15.7] | 12.2 [10.8–14.1] | 12.6 [11.0–14.5] | 0.045 |
Tidal volume (mL/kg of body weight) | NA | NA | 7.6 [7.1–8.4] | 6.8 [6.2–7.8] | 7.1 [6.1–8.4] | 0.10 |
Edi peak (μV) | NA | NA | NA | 4.7 [2.2–7.4] | 4.9 [2.8–8.7] | 0.35 |
Edi min (μV) | NA | NA | NA | 1.6 [0.6–3.3] | 1.8 [0.9–3.2] | 0.55 |
Pressure support (cmH2O) | NA | NA | NA | NA | 7 [5–8] | NA |
NAVA level (cmH2O/μV) | NA | NA | NA | 1.6 [1.0–1.9] | NA | NA |
Lung injury score | NA | NA | 3.0 [2.8–3.3] | 2.5 [1.8–3.8] | 3.0 [2.0–4.0] | 0.97 |