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Fig. 5 | Respiratory Research

Fig. 5

From: Construction of asthma related competing endogenous RNA network revealed novel long non-coding RNAs and potential new drugs

Fig. 5

The potential mechanism of drugs in asthma. (a): The potential mechanism of Tretinoin (ATRA) in asthma. ATRA decreased Th2 cytokines by inhibiting GATA-3 and up-regulating T-bet expression, also, ATRA inhibited the expression of RORγt, thus decreased the level of IL-17A and the downstream proinflammatory factors. (b): The potential mechanism of Quercetin in asthma. Quercetin inhibited gene expression of pro-inflammatory cytokine (TNF-a, IL-1b, IL-6, and IL-8) by regulating the activation of NF-κB and p38 MAPK

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