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Table 5 Management of DIH

From: The clinical impact of drug-induced hepatotoxicity on anti-tuberculosis therapy: a case control study

N = 168

DIH

(n = 20)

Non-DIH

(n = 148)

P-value

Onset time of DIH from treatment commencement, days

61.9 ± 60.3

  

 Hepatotonics

 Administration

17 (85.0)

24 (16.2)

<  0.001

 Drug number

1.40 ± 0.75

0.19 ± 0.46

0.001

 Medication use rate

0.37 ± 0.29

0.06 ± 0.17

<  0.001

Re-introduction methods

 Recommence full-dose drugs after 1 week

8 (40.0)

  

 Regimen change

7 (35.0)

  

 Start with low dose drugs followed by stepwise increases and addition of more drugs

3 (15.0)

  

 Addition of full-dose drugs at intervals of 1 week

2 (10.0)

  
  1. Data are presented as n (%) or means ± SDs. DIH drug-induced hepatotoxicity