N = 168 | DIH (n = 20) | Non-DIH (n = 148) | P-value |
---|---|---|---|
Onset time of DIH from treatment commencement, days | 61.9 ± 60.3 | ||
Hepatotonics | |||
Administration | 17 (85.0) | 24 (16.2) | < 0.001 |
Drug number | 1.40 ± 0.75 | 0.19 ± 0.46 | 0.001 |
Medication use rate | 0.37 ± 0.29 | 0.06 ± 0.17 | < 0.001 |
Re-introduction methods | |||
Recommence full-dose drugs after 1 week | 8 (40.0) | ||
Regimen change | 7 (35.0) | ||
Start with low dose drugs followed by stepwise increases and addition of more drugs | 3 (15.0) | ||
Addition of full-dose drugs at intervals of 1 week | 2 (10.0) |