Fig. 4

Effect of SU1498 on VEGF-induced RhoA activation and MUC5AC expression in PBECs. PBECs were incubated with indicated doses of SU1498 for 2 h before treatment with VEGF (50 ng/ml) for 24 h, and then western blotting analysis for RhoA activation was performed. Total RhoA was used as a loading control (A). PBECs were incubated with indicated doses of SU1498 for 2 h before treatment with VEGF (50 ng/ml) for 24 h, western blotting analysis for MUC5AC activation was performed. β-actin was used as a loading control (B). All data are representative of three independent experiments. The blots were quantified by densitometry. Values represent the means ± SEM. ^*P < 0.05 vs. control; ^# P < 0.05 vs. VEGF alone; n = 3