Respiratory Research

Table 3 Regression analysis for the association of serum bilirubin levels with the 6-min walking distance and quality of life index^a

From: Serum bilirubin level is associated with exercise capacity and quality of life in chronic obstructive pulmonary disease

	6 MW distance, m		CAT		SGRQ
	estimated mean (SE)	P-value	estimated mean (SE)	P-value	estimated mean (SE)	P-value
Whole group
Univariate
Baseline bilirubin	30.1 (14.3)	0.036	0.3 (1.3)	0.835	2.5 (2.9)	0.388
Clustered analysis	42.3 (12.5)	0.001	−2.40 (1.1)	0.028	−0.9 (2.6)	0.735
Multivariate^b
Baseline bilirubin	20.5 (12.2)	0.094	0.4 (1.2)	0.746	2.9 (2.5)	0.261
Clustered analysis	31.0 (11.0)	0.005	−1.9 (0.9)	0.048	0.5 (2.2)	0.826
GOLD I-II
Univariate
Baseline bilirubin	38.6 (16.8)	0.023	−2.8 (1.5)	0.057	−2.2 (3.2)	0.498
Clustered analysis	52.4 (15.0)	0.001	−3.5 (1.2)	0.003	−3.1 (2.5)	0.218
Multivariate^b
Baseline bilirubin	27.6 (14.8)	0.062	−2.1 (1.5)	0.154	−0.6 (3.2)	0.844
Clustered analysis	41.5 (13.3)	0.002	−2.8 (1.2)	0.017	−1.3 (2.6)	0.61
GOLD III-IV
Univariate
Baseline bilirubin	22.9 (25.4)	0.367	3.6 (2.2)	0.105	7.5 (4.6)	0.111
Clustered analysis	27.7 (19.8)	0.162	−0.7 (1.6)	0.666	2.3 (4.1)	0.569
Multivariate^b
Baseline bilirubin	26.7 (20.4)	0.192	2.9 (1.9)	0.139	6.4 (4.2)	0.128
Clustered analysis	20.6 (16.8)	0.219	−0.3 (1.2)	0.818	2.1 (3.0)	0.49

^a ‘baseline bilirubin’ is the results of regression analysis for clinical outcomes according to the baseline bilirubin levels. ‘Clustured analysis’ is the results of regression analysis for clinical outcomes and repeated measured serum bilirubin levels
^b Adjusted for age, sex, body mass index, smoking (current and former), and baseline forced expiratory volume in 1 s
6 MW 6-min walking, CAT COPD assessment test, SGRQ St. George’s Respiratory Questionnaire, SE standard error, GOLD Global Initiative for Chronic Obstructive Lung Disease

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ISSN: 1465-993X

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