Table 2 Regression analysis for the relationship between serum bilirubin levels and pulmonary functiona
FEV1, L | FVC, L | FEV1/FVC, % | ||||
|---|---|---|---|---|---|---|
estimated mean (SE) | P-value | estimated mean (SE) | P-value | estimated mean (SE) | P-value | |
Whole group | ||||||
Univariate | ||||||
Baseline bilirubin | 0.08 (0.09) | 0.382 | 0.18 (0.12) | 0.121 | − 0.52 (1.84) | 0.776 |
Clustered analysis | 0.05 (0.09) | 0.585 | 0.13 (0.11) | 0.255 | − 0.33 (1.75) | 0.85 |
Multivariateb | ||||||
Baseline bilirubin | 0.04 (0.08) | 0.607 | 0.11 (0.11) | 0.322 | −0.45 (1.72) | 0.792 |
Clustered analysis | 0.02 (0.08) | 0.798 | 0.05 (0.10) | 0.662 | 0.08 (1.55) | 0.959 |
GOLD I-II | ||||||
Univariate | ||||||
Baseline bilirubin | 0.19 (0.09) | 0.038 | 0.34 (0.14) | 0.017 | 0.23 (1.76) | 0.898 |
Clustered analysis | 0.14 (0.09) | 0.115 | 0.21 (0.14) | 0.116 | 1.21 (1.52) | 0.428 |
Multivariateb | ||||||
Baseline bilirubin | 0.11 (0.08) | 0.169 | 0.19 (0.12) | 0.111 | −0.08 (1.69) | 0.962 |
Clustered analysis | 0.06 (0.07) | 0.428 | 0.07 (0.12) | 0.561 | 0.94 (1.36) | 0.489 |
GOLD III-IV | ||||||
Univariate | ||||||
Baseline bilirubin | −0.04 (0.09) | 0.622 | −0.02 (0.18) | 0.925 | −0.52 (2.39) | 0.829 |
Clustered analysis | −0.11 (0.08) | 0.169 | −0.02 (0.15) | 0.916 | −2.79 (2.55) | 0.273 |
Multivariateb | ||||||
Baseline bilirubin | −0.07 (0.08) | 0.349 | −0.06 (0.17) | 0.708 | −0.91 (2.31) | 0.694 |
Clustered analysis | −0.12 (0.07) | 0.103 | −0.06 (0.14) | 0.682 | −2.59 (2.42) | 0.285 |