Variables | Stage III (n = 37) | Stage IV (n = 51) | P value |
---|---|---|---|
Age | |||
 Median (Range) – years | 66.0 (41-79) | 64.0 (36-89) | 0.56 |
Age distribution | |||
 < 75 – no. (%) | 30 (81.1) | 43 (84.3) | 0.69 |
 ≥ 75 – no. (%) | 7 (18.9) | 8 (15.7) |  |
Sex – no. (%) | |||
 Male | 29 (78.4) | 30 (58.8) | 0.06 |
 Female | 8 (21.6) | 21 (41.2) |  |
Smoking status | |||
 Current | 16 (43.2) | 19 (37.3) | 0.25 |
 Former | 13 (35.1) | 13 (25.5) |  |
 Never | 8 (21.6) | 19 (37.3) |  |
 BMI | 22.2 ± 3.2 | 22.2 ± 3.4 | 0.74 |
Histological characteristics of tumor – no. (%) | |||
 Adenocarcinoma | 20 (54.1) | 41 (80.4) | < 0.05 |
 Large cell carcinoma | 0 | 1 (2) |  |
 Squamous cell carcinoma | 9 (24.3) | 3 (5.9) |  |
 Not otherwise specified | 6 (16.2) | 2 (3.92) |  |
 Other cell types | 2 (5.41) | 4 (7.84) |  |
 EGFR mutation status Positive/Negative/Unknown | 4 / 9 / 24 | 13 / 13 / 25 | 0.19 |
ECOG performance status – no. (%) | |||
 1 | 17 (46.0) | 22 (43.1) | 0.79 |
 0 | 20 (54.1) | 29 (56.9) |  |
 Primary tumor diameter (mm; mean ±SD) | 36.3 ± 19.3 | 34.1 ± 15.3 | 0.91 |
N factor - no. (%) | |||
 N3 | 10 (8.11) | 15 (29.4) | 0.26 |
 N2 | 22 (59.5) | 19 (37.3) |  |
 N1 | 2 (5.41) | 4 (7.8) |  |
 N0 | 3 (8.11) | 13 (25.5) |  |
M factor - no. (%) | |||
 M1c | 0 | 9 (17.6) |  |
 M1b | 0 | 14 (27.5) |  |
 M1a | 0 | 28 (54.9) |  |
 Total metastatic number at initial diagnosis | 0 | 5.51 ± 4.13 |  |