The matrikine acetyl-proline-glycine-proline and clinical features of COPD: findings from SPIROMICS

Respiratory Research

Table 4 Associations between AcPGP and Severe COPD exacerbations

	Unadjusted			Adjusted
	OR	95% CI	P-value	OR	95% CI	P-value
Sputum AcPGP (quartiles)	2.03	1.21–3.40	0.007	1.75	1.04–2.97	0.037
Elevated sputum AcPGP (above median)	6.01	1.67–21.6	0.006	4.86	1.28–18.4	0.020
Plasma AcPGP (quartiles)	0.98	0.63–1.51	0.92	1.01	0.65–1.58	0.95
Elevated plasma AcPGP (above median)	0.94	0.35–2.49	0.90	1.18	0.41–3.3	0.77

Logistic regression models were adjusted for age, sex, FEV1 percent predicted, prior severe AECOPD, and current smoking status

ISSN: 1465-993X