Skip to main content
Fig. 6 | Respiratory Research

Fig. 6

From: Intra-tracheal administration of a naked plasmid expressing stromal derived factor-1 improves lung structure in rodents with experimental bronchopulmonary dysplasia

Fig. 6

Anti-inflammatory effects of JVS-100 in experimental BPD. a Lung sections stained with MAC-3 (brown) showing increased MAC-3 positive cells/HPF in hyperoxia-exposed pups. Original magnification X 200. Scale bars are 50 μm. b IT JVS-100 significantly reduced MAC-3pos cells/HPF and (c) BAL cell count in hyperoxia-exposed pups. d Decrease in the pro-inflammatory cytokine IL-1β and (e) increase in the anti-inflammatory cytokine, IL-10 in the hyperoxia-exposed JVS-100 treated pups (P < 0.05; * RA-PL vs hyperoxia-PL or hyperoxia-JVS-100, **hyperoxia-PL vs hyperoxia-JVS-100; N = 6 animals/group). A representative Western blot is shown in the lower panel normalized to β-Actin. RA is room air and O2 is hyperoxia

Back to article page

Respiratory Research

ISSN: 1465-993X

Contact us