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Fig. 5 | Respiratory Research

Fig. 5

From: Intra-tracheal administration of a naked plasmid expressing stromal derived factor-1 improves lung structure in rodents with experimental bronchopulmonary dysplasia

Fig. 5

Effects of JVS-100 on pulmonary hypertension and vascular remodeling in experimental BPD. IT JVS-100 significantly decreased (a) right ventricular systolic pressure (RVSP) and (b) RV/LV + S (weight ratio of right ventricle to left ventricle and septum) in hyperoxia-exposed animals (c) Lung sections stained with α-smooth muscle actin (red) demonstrating improved vascular remodeling in hyperoxia-exposed pups treated with IT JVS-100. Magnification X 200. Scale bars are 50 μm. (d) Reduced muscularized vessels in the lungs of hyperoxia-exposed animals after IT JVS-100. (P < 0.05; * RA-PL vs hyperoxia-PL or hyperoxia-JVS-100; ** hyperoxia-PL vs hyperoxia-JVS-100; N = 19–20 animals/group)

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