DNA methylation is associated with lung function in never smokers

de Vries, Maaike; Nedeljkovic, Ivana; van der Plaat, Diana A.; Zhernakova, Alexandra; Lahousse, Lies; Brusselle, Guy G.; Amin, Najaf; van Duijn, Cornelia M.; Vonk, Judith M.; Boezen, H. Marike

doi:10.1186/s12931-019-1222-8

Respiratory Research

Table 5 Overview of CpG location, gene annotation, gene function and literature comparison of the top 36 CpG-sites of the meta analysis

From: DNA methylation is associated with lung function in never smokers

CpG-site	CpG location	Gene annotation	Gene function	Previously associated with lung function
cg10012512	7:157224041	Intergenic	NA	Yes^a
cg02885771	6:144163654	LTV1	Involved in ribosome biogenesis	No
cg25105536	6:97372436	KLHL32	Only described as protein coding gene	No
cg20102034	2:74653166	RTKN	Negative regulator of GTPase activity of Rho proteins	Yes^a
cg03703840	11:93394809	KIAA1731	Mediating of centriole-to-centrosome conversion at late mitosis	No
cg21614201	4:119888794	SYNPO2	Only described as protein coding gene	No
cg07957088	20:62196387	PRIC285	Nuclear transcriptional co-activator for peroxisome proliferator activated receptor alpha	Yes^a
cg05304461	1:11019377	C1orf127	Only described as protein coding gene	No
cg11749902	8:41093619	Intergenic	NA	Yes^a
cg02207312	11:60674164	PRPF19	Involved in cell survival and DNA repair	No
cg19734370	17:78444348	NPTX1	Exclusively localized to the nervous system as binding protein for taipoxin	Yes^a
cg03077331	17:80693076	FN3K	Catalyzes the phosphorylation of fructosamines	Yes^a
cg18387671	17:27920246	ANKRD13B	Only described as protein coding gene	Yes^a
cg03224276	16:72829831	ZFHX3	Regulates myogenic and neuronal differentiation	No
cg02137691	4:1805671	FGFR3	Involved in bone development and maintenance	No
cg25884324	15:91482502	UNC45A	Regulator of the progesterone receptor chaperoning pathway	No
cg27158523	6:149867355	PPIL4	Involved in protein folding, immunosuppression and infection of HIV-1 virions	Yes^a
cg01157143	11:19478542	NAV2	Plays a role in cellular growth and migration	No
cg07160694	14:69619856	DCAF5	Only described as protein coding gene	No
cg22127773	17:7754785	KDM6B	Demethylation of di- or tri-methylated lysine 27 of histone H3	Yes^a
cg20939319	8:30707701	TEX15	Involved in cell cycle processes of spermatocytes	No
cg02206852	17:27030540	PROCA1	Only described as protein coding gene	No
cg17075019	10:79541650	Intergenic	NA	Yes^a
cg25556432	2:239628926	Intergenic	NA	Yes^a
cg22742965	2:192891657	TMEFF2	Cellular context-dependent oncogene or tumor suppressor	Yes
cg16734845	15:44781962	CTDSPL2	Only described as protein coding gene	No
cg09108394	16:23850106	PRKCB	As kinase involved in diverse cellular signaling pathways	No
cg10034572	2:160921789	Intergenic	NA	No
cg20066227	10:16564552	C1QL3	Only described as protein coding gene	No
cg07148038	6:32061160	TNXB	Anti-adhesive protein involved in matrix maturation during wound healing	Yes^a
cg23396786	2:73299151	SFXN5	Only described as protein coding gene	Yes^a
cg06218079	17:80834228	TBCD	As co-factor D involved in the correct folding of beta-tubulin	No
cg06982745	10:72454006	ADAMTS14	The matured enzyme is involved in the formation of collagen fibers	No
cg05946118	16:8985638	Intergenic	NA	Yes^a
cg08065963	16:8985593	Intergenic	NA	Yes^a
cg12064372	12:30948792	Intergenic	NA	Yes^a

^aOnly observed in study by de Vries et al. in never smokers; Gene function obtained by www.genecards.org

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ISSN: 1465-993X

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