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Table 6 Data from the published ASV-real-life and non comparative studies (only studies with more than 70 patients were included; data concern the whole population)

From: What is the remaining status of adaptive servo-ventilation? The results of a real-life multicenter study (OTRLASV-study)

 

N

/

C

Main sub-groups analysis reported

Prevalence of related SA comorbidity/etiology

CPAP trial before ASV

Duration of ASV

/

ASV-adherence

Initial AHI/h

/

Final AHI/h or AHIflow/h

Initial Epworth

/

Final Epworth

Carnevale et al., 2011 [10].

Retrospective

74

/

2

55% non-CHF

and

45% CHF

NA CHF with LVEF≤45%

NA CHF with LVEF> 45%

17% N, NA R, NA O, 28% I

15/74 patients

Duration of the trial NA

36 ± 18 months

/

75.6% > 3 h/jour

53.0 ± 23.8/h

/

5.9 ± 8.0/h

8.9 ± 5.3

/

NA

Momomura et al., 2015 [11].

Retrospective

115

/

16

24% ASV-discontinued CHF

and

76% ASV-continued CHF

NA CHF (LVEF≤45%)

NA CHF (LVEF> 45%)

NA N, NA R, NA O, NA I

No CPAP trial

NA

/

NA

28.8 ± 19.2/h for ASV-discontinued CHF

and 24 ± 21.3/h for ASV-continued CHF/NA

NA

/

NA

Malfertheiner et al., 2017 [12].

Retrospective

285

/

2

32% Cardiac center

68% Pulmonary center

39% CHF with LVEF≤45%

40% CHF with LVEF> 45%

0% N, NA R, 0.4% O, 10% ICSA

1 night for 86 CSA patients and median trial of 17 days for 178 OSA patients

NA

/

NA

NA

/

NA

9 ± 4.5

/

NA

Randerath et al., 2017 [13].

Retrospective

293

/

1

57% CSA, 36% OSA,

and presence of risk criteria (LVEF ≤45% and CSA)

16% CHF with LVEF≤45%

23% CHF with LVEF> 45%

NA N, NA R, 8% O, NA I

NA

NA

/

NA

46.4 ± 20.5/h

/

NA

7.8 ± 4.5

/

5.4 ± 3.7

Oldenburg et al., 2019 [8].

Retrospective

224

/

1

100% CHF

and LVEF ≤45%

and AHI ≥ 15/h with predominant central pattern

NA

No CPAP trial

24 months

65.9% > 4 h/day

at 24 months

37.7 ± 13.4

/

2.8 ± 3.2/h

at 24 months

NA

/

NA

Jaffuel et al.

Prospective

177

/

5

59.3% CSA, 20.3% OSA, 20.3% TECSA (11 patients with LVEF≤45% and CSA were excluded)

7.3% CHF with LVEF≤45%

51.4% CHF with LVEF> 45%

12.4% N, 4.5% R, 3.4% O, 9.6% I

91/177

Duration of the trial NA

34.5 (21.1–59.5) months

/

87% > 4 h/day

50/h (38–62)

/

1.9/h (0.7–3.8)

10 (6–13.5)

/

6 (3–9)

  1. AHI Apnea hypopnea index, AHIflow Apnea hypopnea index estimated by the device, CHF Chronic heart failure, CSA Central sleep apnea, TECSA Treatment emergent central sleep apnea, I Idiopathic CSA, LVEF Left ventricular ejection fraction, N/C Number of patients and centres, N Neurological comorbidity/etiology, NA Not available, O Opioid comorbidity/etiology, OSA Obstructive sleep apnea, R Renal comorbidity/etiology, SA Sleep apnea. Results are expressed as means ± SD or medians and quartiles as reported in the original publication