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Table 1 Respiratory parameters monitored over time. Dynamic lung-thorax compliance (Cdyn), partial pressure of oxygen (PaO2), partial pressure of carbon dioxide (PaCO2), oxygen saturation (SaO2), and arterial pH before (basal value, BV) and after induced ARDS and within 3 h after administration of the therapy (Th) in two-hit ARDS untreated group (Control), and ARDS groups treated with poractant alfa or rSP-C33Leu surfactant. Data are presented as means ± SD

From: Synthetic surfactant with a recombinant surfactant protein C analogue improves lung function and attenuates inflammation in a model of acute respiratory distress syndrome in adult rabbits

 

BV

ARDS

0.5 h Th

1 h Th

1.5 h Th

2 h Th

2.5 h Th

3 h Th

Cdyn (ml/cmH2O)

 Control

2.2 ± 0.4

1.8 ± 0.1

1.4 ± 0.2

1.4 ± 0.3

1.3 ± 0.2

1.2 ± 0.1

1.1 ± 0.2

1.1 ± 0.2

 Poractant alfa

2.3 ± 0.4

2.0 ± 0.1

1.8 ± 0.3**

1.7 ± 0.2*+

1.7 ± 0.2**

1.6 ± 0.2**

1.5 ± 0.2**

1.4 ± 0.2*

 rSP-C33Leu

2.2 ± 0.5

2.0 ± 0.2

1.5 ± 0.2

1.4 ± 0.1

1.5 ± 0.2

1.5 ± 0.2*

1.3 ± 0.3

1.2 ± 0.2

PaO2 (kPa)

 Control

45.7 ± 6.0

8.6 ± 3.0

12.5 ± 7.4

15.7 ± 8.7

12.1 ± 5.6

11.9 ± 5.5

11.8 ± 6.2

14.1 ± 3.0

 Poractant alfa

41.0 ± 8.0

9.7 ± 4.4

40.9 ± 13.4**

45.4 ± 22.9*

49.8 ± 14.0***+

46.2 ± 12.2***

48.6 ± 13.4***

48.0 ± 11.7***

 rSP-C33Leu

45.4 ± 6.2

11.1 ± 6.6

38.7 ± 17.4**

35.9 ± 23.0

31.7 ± 17.0*

36.3 ± 14.8**

34.4 ± 14.1**

33.5 ± 13.2*

PaCO2 (kPa)

 Control

5.9 ± 1.2

4.4 ± 1.4

6.4 ± 1.1

7.3 ± 0.7

6.7 ± 0.7

7.3 ± 1.0

7.7 ± 1.9

8.1 ± 1.8

 Poractant alfa

6.5 ± 2.0

4.1 ± 1.0

6.1 ± 1.2

6.5 ± 1.9

6.4 ± 1.6

6.3 ± 1.4

6.3 ± 1.4

6.5 ± 1.3

 rSP-C33Leu

5.2 ± 1.4

3.8 ± 0.7

5.7 ± 0.5

5.9 ± 0.6

6.3 ± 1.3

5.9 ± 0.8

6.1 ± 1.1

6.5 ± 0.9

SaO2 (%)

 Control

99.0 ± 1.5

92.1 ± 7.3

94.8 ± 5.4

92.2 ± 8.5

89.4 ± 8.6

85.8 ± 11.1

87.2 ± 13.3

80.8 ± 16.8

 Poractant alfa

96.9 ± 2.8

88.7 ± 6.3

96.4 ± 1.7

95.6 ± 3.6

95.6 ± 3.1

95.7 ± 2.8*

96.6 ± 1.9

96.4 ± 2.3**

 rSP-C33Leu

97.3 ± 1.6

92.1 ± 5.4

96.2 ± 3.4

95.7 ± 4.3

96.5 ± 4.1

96.5 ± 4.4*

97.3 ± 3.4*

97.3 ± 3.3**

pH

 Control

7.5 ± 0.1

7.5 ± 0.1

7.4 ± 0.1

7.3 ± 0.1

7.3 ± 0.0

7.3 ± 0.1

7.3 ± 0.2

7.2 ± 0.2

 Poractant alfa

7.4 ± 0.1

7.6 ± 0.1

7.4 ± 0.1

7.4 ± 0.1

7.4 ± 0.1

7.4 ± 0.1

7.4 ± 0.1

7.4 ± 0.1

 rSP-C33Leu

7.5 ± 0.1

7.5 ± 0.1

7.4 ± 0.0

7.4 ± 0.0

7.3 ± 0.1

7.4 ± 0.0

7.3 ± 0.0

7.3 ± 0.0

  1. Statistical comparisons: for Poractant alfa & rSP-C33Leu vs. Control *p < 0.05, **p < 0.01, ***p < 0.001; for Poractant alfa vs. rSP-C33Leu +p < 0.05
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Respiratory Research

ISSN: 1465-993X

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