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Fig. 1 | Respiratory Research

Fig. 1

From: Synthetic surfactant with a recombinant surfactant protein C analogue improves lung function and attenuates inflammation in a model of acute respiratory distress syndrome in adult rabbits

Fig. 1

Experimental set-up and changes in respiratory parameters. (a) Scheme of experimental protocol and changes in PaO2; respiratory parameters: (b) staticc lung-thorax compliance (Cstat, ml/cmH2O), (c) the ratio of arterial oxygen partial pressure to fraction of inspired oxygen (P/F, kPa), (d) oxygenation index (OI), (e) airway pressure (Paw, kPa), (f) alveolar-arterial gradient (AaG, kPa) and (g) ventilation efficiency index (VEI) before (basal value, BV) and ARDS and during 3 h after first dose of therapy. The arrows indicate administration of surfactant therapy. Data are presented as means ± SD. Statistical comparisons: for poractant alfa vs. Control *p < 0.05, **p < 0.01, ***p < 0.001; for rSP-C33Leu vs. Control #p < 0.05, ##p < 0.01, ###p < 0.001; for poractant alfa vs. rSP-C33Leu +p < 0.05

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Respiratory Research

ISSN: 1465-993X

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