The association of cognitive functioning as measured by the DemTect with functional and clinical characteristics of COPD: results from the COSYCONET cohort

Table 6 Results of the path analysis model

Regression	Estimate	S.E.	C.R.	Standardized.	P
FVC ← CRP	−4.059	.799	−5.078	−.114	p < 0.001
CaO₂ ← FVC	.012	.002	6.180	.139	p < 0.001
6-MWD ← FVC	2.564	.109	23.532	.468	p < 0.001
6-MWD ← CaO₂	3.471	1.263	2.749	.054	.006
6-MWDs←CRP	−19.386	3.845	−5.041	−.100	p < 0.001
DemTect←CaO₂	.115	.040	2.903	.065	.004
DemTect←CRP	−.326	.121	−2.681	−.061	.007
DemTect←6-MWD	.003	.001	4.417	.101	p < 0.001
History of CI ← DemTect	−.005	.002	−3.075	−.070	.002
mMRC←6-MWD	−.004	.000	−19.576	−.428	p < 0.001
mMRC←FVC	−.008	.001	−8.072	−.176	p < 0.001
SGRQ (impact) ← DemTect	−.315	.129	−2.450	−.044	.014
SGRQ (impact) ← FVC	−.062	.022	−2.783	−.057	.005
SGRQ (impact) ← History of CI	7.061	1.626	4.341	.077	p < 0.001
SGRQ (impact) ← mMRC	9.988	.479	20.868	.437	p < 0.001
SGRQ (impact) ← 6-MWD	−.044	.004	−9.952	−.221	p < 0.001

The panel refers to the directed arrows (regression terms) depicted in Fig. 3, whereby the left part lists the arrows shown in this figure. The right part shows the results of the corresponding statistical tests. The first column of the right part shows the non-standardized estimate of the respective regression coefficient, the second column the standard error (S.E.) of this coefficient, the third column the ratio of these two values (critical ratio, C.R.) which is used for significance testing. The fourth column shows the standardized estimates of the regression coefficients shown in the first column. The last column shows the significance level based on the generalized least squares (GLS) procedure of AMOS. In the path analysis model, CRP values were logarithmically transformed (log10), in order to account for the skewness of data and obtain a distribution closer to normal. For abbreviations of symbols see text

ISSN: 1465-993X