The association of cognitive functioning as measured by the DemTect with functional and clinical characteristics of COPD: results from the COSYCONET cohort

Table 4 Dependence of the modified DemTect score on clinical and functional parameters

	Unstandardized regression coefficient	SEM	95% Confidence Interval		p-value
	Unstandardized regression coefficient	SEM	Lower limit	Upper limit	p-value
Age ≥ 60 y *	0.003	0.225	−0.438	0.445	0.989
Female	1.352	0.141	1.076	1.628	< 0.001
Age [y]	−0.088	0.012	−0.112	− 0.064	< 0.001
Current smoker	−0.373	0.149	−0.666	− 0.081	0.012
Diagnosis of CI	−0.731	0.284	−1.287	−0.175	0.010
mMRC	0.183	0.092	0.002	0.364	0.047
SGRQ impact score	−0.009	0.004	−0.017	− 0.002	0.017
6-MWD [m]	0.002	0.001	0.001	0.004	0.007
log₁₀CRP [mg/100 mL]	−0.317	0.121	−0.554	− 0.079	0.009
FVC [% predicted GLI]	0.005	0.004	−0.003	0.013	0.187
CaO₂ [mL/100 mL]	0.110	0.039	0.033	0.188	0.005

The table shows the results of multivariable linear regression analyses in terms of the unnormalized regression coefficients as well as 95%-confidence intervals. The level of significance was set at p < 0.05. *Indicator variable with values 0 and 1 for ages < and ≥ 60 years of age, respectively. CRP values were included as log₁₀-transformed values, therefore the respective coefficient must be interpreted as change in the respective DemTect score for a tenfold increase in CRP level (log₁₀(10) = 1). CI = cognitive impairment. When repeating the same analysis while including the activity and symptom scores of the SGRQ, the activity score turned out to be not statistically significant (p = 0.120), while the symptom score was only borderline significant (p = 0.048) and the impact score remained significant (p = 0.000313)

ISSN: 1465-993X