Fig. 3

Polarization of circulating Tfh-cell subsets in IPF and healthy cases. a Representative fluorescence-activated cell sorting profiles indicating Tfh1 cells (CXCR3⁺CCR6⁻), Tfh2 cells (CXCR3⁻CCR6⁻), and Tfh17 cells (CXCR3⁻CCR6⁺). Plots were pregated on CD3⁺CD4⁺CXCR5⁺ cells and examined by the levels of CXCR3 and CCR6. The numbers indicate the proportion of cells in the gate. b–d The proportions of Tfh-cell subsets among all Tfh cells are shown in the panel. b Tfh1 cells, (c) Tfh2 cells and (d) Tfh17 cells. Tfh, follicular helper T; IPF, idiopathic pulmonary fibrosis